![Screen Shot 2023 12 10 At 1.18.45 Pm Screen Shot 2023 12 10 At 1.18.45 Pm](https://resolvetherapeutics.com/wp-content/uploads/2023/12/Screen-Shot-2023-12-10-at-1.18.45-PM.jpg)
RSLV-621 is a potent Interferon (IFN) antagonist that is comprised of a soluble IFN receptor fused to IgG1 Fc. The molecule demonstrates subnanomolar IC50 inhibition of major interferons including IFN- and IFN-. Interferon is a validated target in autoimmune disease with demonstrated efficacy in SLE, Lupus nephritis, and Systemic Sclerosis. Its smaller molecular weight, roughly 25% of a monoclonal antibody, may offer access to cellular compartments difficult to penetrate with a large 180 kDa monoclonal antibody. Since, inhibiting the IFN pathway has proven efficacy in SLE, there is a rapid path to clinical proof-of-concept and go/no-go decision into larger pivotal trials for RSLV-621.